Preheat the Oven: Preheat your oven to 375°F (190°C). Lightly grease a baking dish with olive oil or butter.
Prepare the Tilapia: Place the tilapia fillets in the baking dish. Pat the fillets dry with paper towels and lightly season with salt and pepper.
Make the Topping: In a medium bowl, mix together the chopped artichokes, Parmesan cheese, mayonnaise (or Greek yogurt), minced garlic, lemon juice, paprika, and Italian herbs. Stir until well combined.
Top the Fish: Spread the artichoke-Parmesan mixture evenly over each tilapia fillet, covering the entire surface.
Bake the Tilapia: Bake the fillets in the preheated oven for 20–25 minutes until the fish is opaque and flakes easily with a fork. If you like a crispier topping, broil for an additional 2–3 minutes at the end.
Serve: Remove the dish from the oven, let it rest for a minute, then serve with your favorite sides, like roasted vegetables, rice, or a salad.