Combine ingredients: Add the blackberries, ketchup, vinegar, brown sugar, honey, Worcestershire sauce, and all seasonings to a medium saucepan. Stir to combine.
Simmer: Bring the mixture to a gentle simmer over medium heat. Reduce heat to low and cook for 15–20 minutes, stirring occasionally, until the berries break down and the sauce thickens.
Blend (optional): For a smoother texture, use an immersion blender to puree the sauce directly in the pot, or transfer it carefully to a blender.
Strain (optional): If you prefer a seedless sauce, pour the blended mixture through a fine mesh strainer, pressing with a spoon to extract all the liquid.
Adjust and cool: Taste and adjust sweetness, smokiness, or heat as desired. Let the sauce cool before serving or storing.